Cloture votes fail in the United States Senate on the Comprehensive Immigration Reform Act of 2007, potentially killing the bill.
- Atlanta Journal-Constitution
- A constitutional amendment to ban same-sex marriage is killed when it fails to gain the three-fifths majority required for cloture in the United States Senate. 49 Senators voted for the motion, and 48 voted against. This also fell far short of the two-thirds majority that would have been required for passage.
- The United States Senate, in a 92-5 vote, confirms Christopher A. Wray as Director of the Federal Bureau of Investigation.
- The American Health Care Act of 2017, an attempt to repeal the Patient Protection and Affordable Care Act, fails passage in the United States Senate.
- The United States Senate rejects "repeal only" propositions of the Patient Protection and Affordable Care Act. United States President Donald Trump lashes out at Republican Senator Lisa Murkowski, who voted against the proposal.
- The U.S. Senate votes to open debate on repealing and possibly replacing Obamacare.
- A hearing in the U.S. Senate is held about alleged human rights violations in the Philippines's war against illegal drugs.
- U.S. Senator John McCain is diagnosed with a malignant brain cancer, glioblastoma multiforme. This is his second battle with cancer, after having been successfully treated for malignant melanoma.
- The United States Senate passed by an overwhelming majority a bill ramping-up sanctions against Russia and against Iran. Language in the measure also reaffirms United States' commitment to NATO.
- The United States Senate confirms Heather Wilson as Secretary of the Air Force.
- United States senators Ben Cardin (D-MD) and Marco Rubio (R-FL) file a bill restricting arms sales to the Philippine National Police over its drug war.